Social disadvantage is associated with impaired increase in salivary diurnal melatonin amplitude throughout pregnancy.

ABSTRACT:

Study objectives

Melatonin regulates daily rhythms and is important for maintaining a healthy pregnancy. Certain socioeconomic factors may affect melatonin release. This study evaluates whether the increase in melatonin with advancing gestation is associated with social disadvantage.

Methods

Data were prospectively collected from a socioeconomically diverse cohort of participants with singleton pregnancies (n = 921) at a Midwest academic center. Participants self-collected saliva every four hours over a 24-hour period once per trimester. Diurnal melatonin concentration was measured, and for each trimester, the maximum and mean diurnal melatonin concentration values were obtained. Cosinor-fitting was performed to obtain peak, mesor, and amplitude values, and melatonin

SUBMITTER: McCarthy RT 

PROVIDER: S-EPMC12535763 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature