Mass-Manufactured Gradient Plasmonic Metasurfaces for Enhanced Mid-IR Spectrochemical Analysis of Complex Biofluids.

ABSTRACT: Mid-infrared (Mid-IR) spectroscopy offers powerful label-free molecular analysis capabilities but faces significant challenges when analyzing complex biological samples. Here, a transformative surface-enhanced infrared absorption spectroscopy (SEIRAS) platform is presented that overcomes fundamental limitations through key innovations. First, high-throughput wafer-scale fabrication of mid-IR plasmonic micro-hole-array (MHA) metasurfaces is demonstrated on free-standing silicon nitride (Si₃N₄) membranes, yielding ≈400 sensor chips per 6-inch wafer. Second, the gradient MHA metasurface design supports spectrally cascaded plasmonic modes, generating over 400 sharp resonance peaks across the 1200-2000 cm^-1 fingerprint region. This approach enables comprehensive

SUBMITTER: Rosas S 

PROVIDER: S-EPMC12535766 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature