Coexistence of Multidrug Resistance and Hypervirulence-Associated Genes in Clinical Carbapenem-Resistant <i>Pseudomonas aeruginosa</i>.

ABSTRACT: The recent worldwide emergence of hypervirulent, multidrug-resistant Pseudomonas aeruginosa represents a critical public health threat. The molecular typing, multidrug resistance (MDR) rates, and hypervirulence-associated genes in carbapenem-resistant P. aeruginosa (CRPA) isolates can vary across geographic locations and patients, highlighting their clinical significance. In this study we investigated the epidemiology and relationship between MDR and the presence of hypervirulence-associated genes in CRPA isolates. Accordingly, we performed antimicrobial susceptibility tests, multilocus sequence typing (MLST), and PCR-based detection of carbapenemase and virulence-associated genes. Notably, 34.9% (139/398) of the isolates were carbapenem-resistant, with 79.1% of these exhibit

SUBMITTER: Cho HH 

PROVIDER: S-EPMC12535857 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature