The association between chronic rhinosinusitis and the risk of dementia: a longitudinal study.

ABSTRACT:

Background

Chronic inflammation status could increase the risk of dementia, and chronic rhinosinusitis (CRS) could cause chronic inflammation status. Therefore, CRS may be associated with dementia. The aim of our study was to investigate the association between CRS and the risk of dementia in the UK Biobank (UKB) cohort.

Materials and methods

A total of 3,64,945 participants were included in this cohort study. CRS information was obtained from the first occurrence date of CRS (Field 131,468) at baseline. A Cox regression model and mediation analysis were performed to measure the association between CRS and dementia.

Results

Chronic rhinosinusitis was significantly associated with an increased risk of Alzheimer's disease (AD) (hazard ratio [HR]: 1.33, 95% CI: 1.04-1.71

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12535962 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature