Administration of statins is correlated with favourable prognosis in lung cancer patients receiving immune checkpoint inhibitors.

ABSTRACT:

Objective

Statins are commonly used for cardiovascular diseases and recent studies have supported their anti-cancer role in numerous human malignancies. This study aims to investigate their prognostic impact in lung cancer patients receiving immune checkpoint inhibitors (ICIs).

Methods

A retrospective analysis was performed based on the clinical data from 235 lung cancer patients who received ICI therapy between 2019 and 2024 in three hospitals. The correlation of statin use with overall survival (OS) or progression-free survival (PFS) was analyzed. Then, a comprehensive bioinformatics analysis was used to identify prognostic target genes of statins and investigate their correlation with immune infiltration, followed by validation in an independent cohort and cellular experi

SUBMITTER: Yang J 

PROVIDER: S-EPMC12535986 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature