Biological markers of treatment response to serotonergic psychedelic therapies: a systematic review.

ABSTRACT:

Background

Results from contemporary clinical trials of serotonergic psychedelic therapies have led to an increasing focus on their potential clinical use across mental disorders. However, studies examining mechanisms of clinical response to psychedelic therapy in psychiatric populations are limited. This review aimed to synthesize evidence from studies examining biomarkers of clinical response to psychedelic therapies.

Data sources and methods

A systematic search of four databases (MedLine, PsycInfo, EMBASE, and Web of Science) for studies investigating treatment response to psychedelic therapies in psychiatric populations that included both clinical outcomes and a related biomarker was conducted on January 10, 2024. Studies were included if they reported on prospective cli

SUBMITTER: Wong S 

PROVIDER: S-EPMC12536141 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature