Glutamine Metabolite Ratios are Related to Thwarted Belongingness and Perceived Burdensomeness: Preliminary Evidence from a Veteran Sample with and Without History of Suicidal Ideation.

ABSTRACT:

Background

Suicidal thoughts and behaviors are an acute public health issue, particularly among US Veterans. The interpersonal-psychological theory of suicide posits that unmet interpersonal needs, specifically thwarted belongingness (TB) and perceived burdensomeness (PB) contribute to desire for death by suicide and increased suicidal ideation (SI). However, little is known about the neurochemical correlates of TB and PB. Prior research using proton magnetic resonance spectroscopy (1H-MRS) has implicated glutamate (Glu) and glutamine (Gln), as well as gamma-aminobutyric acid (GABA), in SI and related psychiatric disorders. The current study sought to examine the relationship between thwarted belongingness and perceived burdensomeness and concentrations of Gln, Glu, and GABA in US

SUBMITTER: Yancey JR 

PROVIDER: S-EPMC12536143 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature