Is Proximal Gastrectomy Oncologically Justifiable for Advanced Siewert II/III Adenocarcinoma of the Esophagogastric Junction?

ABSTRACT:

Purpose

The oncological safety of proximal gastrectomy (PG) for advanced Siewert II/III adenocarcinoma of the esophagogastric junction (AEG) remains controversial. We compared the long-term oncological outcomes of PG and total gastrectomy (TG) to refine the indications for PG.

Materials and methods

This dual-center retrospective study included 443 patients with pT2-4NanyM0 Siewert II/III AEG who underwent PG (n=192) or TG (n=251). Propensity score matching yielded 149 matched pairs. Perioperative outcomes, overall survival (OS), recurrence-free survival (RFS), and recurrence patterns were analyzed. Logistic regression analysis was used to assess risk factors for perigastric lymph nodes (PLN) recurrence after PG and key distal lymph nodes (KDLN) metastases after TG. The thera

SUBMITTER: Wang H 

PROVIDER: S-EPMC12536192 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature