Rose Bengal Is a Precise Pharmacological Tool Triggering Chloroplast-Driven Programmed Cell Death in Plants, Dependent on Calcium and Mitochondria, and Associated With Early Transcriptional Reprogramming.

ABSTRACT: Programmed cell death (PCD) mediates plant development and environmental interactions. Photosynthesis-derived singlet oxygen (¹O₂) is one of key reactive oxygen species (ROS) implicated in acclimation and PCD responses to environmental stress conditions. Using Arabidopsis thaliana cell suspension culture system, we characterized the PCD induced by Rose Bengal (RB), a photosensitizer generating ¹O₂ upon light exposure. Obtained results reiterated that RB-induced PCD is light and chloroplast dependent. Further, we demonstrate that PCD induced by RB involves calcium signaling and mitochondria, thus sharing common features with other forms of regulated cell death in plants. The PCD induced by RB was associated with early transcriptional reprogramming, in

SUBMITTER: Jnaid Y 

PROVIDER: S-EPMC12536220 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature