Urinary Histamine Not Associated with Severity of Symptoms of ADHD and Emotional Dysregulation: A Cross-sectional Secondary Data Analysis from the Micronutrients for ADHD in Youth (MADDY) Study.

ABSTRACT:

Objectives

Histamine, a critical regulator of attention and inflammatory processes, may play a role in symptoms of attention-deficit/hyperactivity disorder (ADHD).

Methods

Data were from the baseline visit of a multi-site randomized controlled trial in children aged 6-12 with symptoms of ADHD and emotional dysregulation, the Micronutrients for ADHD in Youth (MADDY) study. Parent-reported intake of high-histamine foods was assessed with the VioScreen questionnaire; symptoms of ADHD with the Child & Adolescent Symptom Inventory, version-5 (CASI-5) Inattention and Hyperactivity/Impulsivity subscales, and emotional dysregulation with the Strengths & Difficulties Questionnaire-Dysregulation Profile. Urinary histamine was analyzed with liquid chromatography-mass spectrometry, with

SUBMITTER: Bruton AM 

PROVIDER: S-EPMC12536302 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature