Towards the Stable Chelation of Radioantimony(V) for Targeted Auger Theranostics.

ABSTRACT: Antimony-119 (¹¹⁹Sb) is one of the most attractive Auger-electron emitters identified to date, but it remains practically unexplored for targeted radiotherapy because no chelators have been identified to stably bind this metalloid in vivo. In a departure from current studies focused on chelator development for Sb(III), we explore the chelation chemistry of Sb(V) using the tris-catecholate ligand TREN-CAM. Through a combination of radiolabeling, spectroscopic, solid-state, and computational studies, the radiochemistry and structural chemistry of TREN-CAM with ^1XX/natSb(V) were established. The resulting [^1XXSb]Sb-TREN-CAM complex remained intact for several days in human serum, signifying high stability under biological conditions. Finally, the first in vivo

SUBMITTER: Olson AP 

PROVIDER: S-EPMC12536330 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature