Melatonin mitigates ovarian aging through regulation of the YTHDF2/m ⁶A/UBE3C axis.

ABSTRACT: Ovarian aging is a natural process characterized by a decline in both the quantity and quality of oocytes, which subsequently leads to diminished fertility, particularly in women over the age of 35. Given the societal trend toward postponing childbirth, it is imperative to understand the molecular mechanisms that underpin ovarian aging to address infertility issues. Melatonin (MT) is recognized for its therapeutic potential in mitigating ovarian aging; however, the specific epigenetic mechanisms involved, particularly concerning m ⁶A methylation, remain inadequately defined. Our investigation demonstrates that MT mitigates ovarian aging in murine models, significantly decreasing m ⁶A methylation levels. In vitro analyses of ovarian granulosa (KGN) cells reveals

SUBMITTER: Xia W 

PROVIDER: S-EPMC12536360 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature