A novel near-infrared fluorescent hERG potassium channel probe for glioblastoma therapy and imaging.

ABSTRACT: Glioblastoma multiforme (GBM) is the most common and malignant type of primary brain tumor, and its therapy remains challenging. The hERG potassium channel represents a promising target for GBM therapy and imaging. However, there are currently few efficient hERG channel inhibitors with low toxicity for cancer therapy. In this work, a novel near-infrared fluorescent probe A8 with high binding affinity for the hERG channel was developed, and then it was encapsulated into an ApoE peptide-modified liposome to improve its transport across the blood-brain barrier and tumor targeting. The obtained liposome, ApoE-Lipo@A8, can significantly suppress the growth of orthotopic glioblastoma xenografts with reduced cardiac toxicity. Additionally, our studies unveil a novel molecular mechanism underlying

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12536447 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature