Circular RNA Cdr1as Modulates Macrophage-Mediated Cardiac Reparative Function.

ABSTRACT:

Background

Mechanisms of macrophage switching from proinflammatory to anti-inflammatory phenotypes are not well understood. Circular RNAs, a new class of noncoding RNAs, are implicated in immune modulation. We recently identified circ-cdr1as as a regulator of macrophage phenotype in bone marrow-derived macrophages; however, its role in immunomodulation during cardiovascular injury remains unknown.

Methods

Cell-specific expression levels of circ-cdr1as were determined in the mouse hearts postmyocardial infarction. Circ-cdr1as was overexpressed in fluorescently labeled bone marrow-derived macrophages and injected into the ischemic myocardium immediately following myocardial infarction. The effect of AAV9 (adeno-associated virus-serotype 9)-mediated systemic delivery of circ-Cd

SUBMITTER: Gonzalez C 

PROVIDER: S-EPMC12536452 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature