Synthesis of triazolo- and tetrazolo-fused 1,4-benzodiazepines via one-pot Ugi-azide and Cu-free click reactions.

ABSTRACT: A one-pot Ugi-azide reaction followed by intramolecular Cu-free azide-alkyne cycloaddition generates a polycyclic scaffold 7 bearing polycyclic triazole, tetrazole, and benzodiazepine rings. This method could be extended for obtaining a more complicated scaffold 8 containing a piperazinone ring.

SUBMITTER: Ma X 

PROVIDER: S-EPMC12536470 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature