Apparent diffusion coefficient for genetic characterization of untreated adult gliomas: A meta-analysis stratified by methods.

ABSTRACT:

Background

Isocitrate dehydrogenase (IDH) mutation and chromosome 1p19q genotyping have become fundamental to the prognostic grouping of adult diffuse gliomas. Apparent diffusion coefficient (ADC) values may enable noninvasive prediction of glioma molecular status. The purpose of this systematic review and meta-analysis was to investigate the diagnostic accuracy of ADC for IDH and 1p19q genotyping, considering measurement techniques and tumor grade.

Methods

A systematic search of PubMed and Cochrane Library databases was performed in December 2024. Studies were grouped according to the ADC parameter measured and the measurement techniques used. A meta-analysis was performed, supplemented by Egger's regression testing. The quality of studies was assessed with the QUADAS-2 too

SUBMITTER: Bhatti F 

PROVIDER: S-EPMC12536491 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature