CircCdh7 induces astrogliosis and neuroinflammation to trigger hypertensive effects in the rostral ventrolateral medulla.

ABSTRACT:

Background

The rostral ventrolateral medulla (RVLM) is a critical vasomotor center that plays a pivotal role in the pathogenesis of hypertension. However, the involvement of circular RNAs (circRNAs) in this nucleus in blood pressure (BP) regulation remains incompletely understood.

Methods

In this study, we investigated functional circRNAs in the RVLM associated with hypertension and elucidated their underlying mechanisms using multiple experimental approaches, including RNA sequencing (RNA-seq), primary cell culture, and intra-RVLM microinjection.

Results

Our results revealed a significantly elevated level of the highly conserved circCdh7 in the RVLM of spontaneously hypertensive rats (SHRs). Downregulation of circCdh7 in the RVLM reduced neuronal excitability, sympat

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12536531 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature