Association between dietary carbohydrate intake and multiple sclerosis risk: a large-scale cohort study.

ABSTRACT:

Introduction

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by neuroinflammation and demyelination. Although diet may influence MS risk, evidence regarding carbohydrate intake remains unclear.

Methods

We examined this association in a prospective cohort of 210,483 participants from the UK Biobank. Dietary carbohydrates were assessed using repeated 24-hour recalls. The diagnosis of MS cases was based on hospital inpatient records coded with the International Classification of Diseases, 10th Revision (ICD-10) code G35. The association between carbohydrate intake and MS risk was analyzed using Cox proportional hazards models.

Results

Over a median follow-up of 13.25 years, 495 incident MS cases were identified. A per interquartile range (IQR) incr

SUBMITTER: Yuan Q 

PROVIDER: S-EPMC12536550 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature