Association between serum 25-hydroxyvitamin D concentrations and platelet to high-density lipoprotein cholesterol ratio: evidence from two population-based studies.

ABSTRACT:

Background

The platelet to high-density lipoprotein cholesterol ratio (PHR) is an emerging marker of inflammation and metabolic health, combining platelet counts and HDL cholesterol (HDL-C) levels. Vitamin D is essential for various physiologic processes, including immune modulation and lipid metabolism. Our study investigates the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and PHR.

Methods

We conducted cross-sectional analyses of two population-based datasets: NHANES (n = 36,238) from the U.S. and the baseline survey of a Chinese cohort study (n = 1,122). Serum 25(OH)D and blood PHR were assessed, with PHR defined as the ratio of platelet count to HDL-C (mmol/L). To examine the associations of 25(OH)D with PHR, we used weighted linea

SUBMITTER: Wang M 

PROVIDER: S-EPMC12536551 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature