Oscillometry Phenotypes in Children With Down Syndrome.

ABSTRACT:

Objective

To evaluate lung function patterns measured by oscillometry in children with Down syndrome and determine associations with pulmonary diagnoses that may co-occur with Down syndrome, including evidence of dysphagia, obstructive sleep apnea, tracheomalacia, and congenital heart disease.

Study design and patients

Cross-sectional study of children with Down syndrome who were enrolled during 2019-2022 at ages 4-18 years old.

Measurements

Children performed oscillometry before and after albuterol administration to obtain respiratory impedance measures of resistance (R) and reactance (X). Aspiration from swallow study, obstructive sleep apnea from polysomnogram, tracheomalacia from flexible bronchoscopy, and congenital heart disease diagnoses were obtained from the

SUBMITTER: Hamlington KL 

PROVIDER: S-EPMC12536560 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature