Akt-FoxO signaling drives co-adaptation to insecticide and host plant stresses in an herbivorous insect.

ABSTRACT:

Introduction

Ongoing interactions between host and herbivorous insect trigger a co-evolutionary arms race. Genetic diversity within insects facilitates their adaptation to phytochemicals and their derivatives, including plant-derived insecticides. Cytochrome P450s play important roles in metabolizing phytochemicals and insecticides, due to their diversity and almost perfect evolution.

Objectives

This study aims to uncover a common molecular mechanism in herbivorous insects by investigating the role of kinase-transcription factor regulation of P450s in conferring tolerance to both insecticides and phytochemicals.

Methods

RNA interference, transcriptome sequencing, insecticide, and phytochemical bioassays were conducted to validate the functions of Akt, FoxO, and candid

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12536606 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature