<i>In Vitro</i> and <i>Ex Vivo</i> evidence that pharmacological induction of the hypoxia response pathway efficiently restricts measles and Nipah virus infections.

ABSTRACT: Airborne RNA viruses of the Paramyxoviridae family are major human pathogens. These include measles virus (MeV) and Nipah virus (NiV), the latter being on the World Health Organization's blueprint list due to its high case-fatality rate and critical risk of emergence. Although an effective vaccine is available for MeV, this is not the case for NiV. Moreover, there is no cure for MeV- or NiV-infected patients that prevents the acute respiratory syndrome or lethal encephalitis. To identify new host factors to target for inhibiting viral growth, a library of metabolic modulators was screened for activity against MeV using an in vitro infection model. Results showed that Molidustat, a pharmacological inhibitor of Prolyl-Hydroxylase Domain (PHD) enzymes, inhibits MeV infection in

SUBMITTER: Canus L 

PROVIDER: S-EPMC12536633 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature