Selective labeling and visualization of viral and bacterial neuraminidases using <i>ortho</i>-quinone methide-based probes.

ABSTRACT: Neuraminidases (NAs) are critical virulence factors in pathogens. In viruses such as influenza A, neuraminidase facilitates the release of virions, thereby enabling infection propagation. In pathogenic bacteria, NA activity has been linked to the pathogenicity of species such as S. pneumoniae, P. aeruginosa, and V. cholerae. Studies suggest that bacterial NAs play roles in mucus degradation, exposing host epitopes to enhance bacterial adhesion, biofilm formation, and bacterial survival. However, the specific mechanisms by which bacterial NAs contribute to pathogenesis remain poorly understood and largely unknown. To gain a deeper understanding of the molecular mechanisms underlying this class of enzymes, highly selective and sensitive strategies are needed for screenin

SUBMITTER: Alvarado-Melendez EI 

PROVIDER: S-EPMC12536644 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature