Investigating the role of neighborhood socioeconomic status and germline genetics on prostate cancer risk.

ABSTRACT: Genetic factors play an important role in prostate cancer (PCa) development with polygenic risk scores (PRS) predicting disease risk across genetic ancestries. However, there are few convincing modifiable factors for PCa and little is known about their potential interaction with genetic risk. Our study explores the role of neighborhood socioeconomic status (nSES)-and how it may interact with PRS-on PCa risk. We analyzed incident PCa cases and controls of European (cases = 5,960; controls = 93,990) and African (cases = 109; controls = 1,226) ancestry from the UK Biobank cohort. Using the English indices of deprivation, a set of validated metrics that quantify lack of resources within geographical areas, we performed logistic regression to investigate the main effects and interactions betwee

SUBMITTER: Judd J 

PROVIDER: S-EPMC12536654 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature