Cognition-associated gray matter volume alterations in long-COVID show sex-specific patterns.

ABSTRACT:

Introduction

The long-term effects of the coronavirus disease 2019 (COVID-19) are a major concern in today's society, with cognitive impairment being an important manifestation. Notably, men and women exhibit differences in disease progression and the prevalence of long-COVID. This study aims to investigate sex differences in cognitively impaired long-COVID individuals and their potential association with alterations in gray matter volume (GMV).

Methods

We conducted MRI at 3 Tesla to investigate brain structural correlates of cognitive impairment in long-COVID patients using voxel-based morphometry (VBM) and compared these patients to a healthy control (HC) group (n=30, female=13, male=17). Long-COVID patients underwent scanning and neuropsychiatric assessment on average 9.9

SUBMITTER: Toepffer A 

PROVIDER: S-EPMC12536713 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature