Contraceptive use and pregnancy in cystic fibrosis: Survey findings from 10 cystic fibrosis centers.

ABSTRACT:

Background

Reproductive life planning is key, now that people with cystic fibrosis (pwCF) may live into their 60s. This study explores contraceptive use, pregnancy trends, and whether concomitant cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy reduces contraceptive effectiveness.

Methods

Females with CF aged 18-45 years from 10 U.S. CF centers completed a self-administered web-based questionnaire. Pregnancy rates were calculated by linear-mixed models with a logit link detected associations with contraception and modulator use.

Results

A total of 561 pwCF (median age of 29 years [IQR 24.9-35.8] years) completed the survey. Most participants (n = 499, 89%) used modulators, and almost all (n = 555, 99%) used contraception. Condoms (n = 448,

SUBMITTER: Godfrey EM 

PROVIDER: S-EPMC12536715 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature