The unique synaptic circuitry of specialized olfactory glomeruli in <i>Drosophila melanogaster</i>.

ABSTRACT: In the Drosophila olfactory system, most odorants are encoded in the antennal lobe in a combinatory way, activating several glomerular circuits. However, odorants of particular ecological role for the fly are encoded through activation of a single specialized olfactory pathway. Comparative analyses of densely reconstructed connectomes of one broadly tuned glomerulus (DL5) and one narrowly tuned glomerulus (DA2) gained detailed insight into the variations of synaptic circuitries of glomeruli with different computational tasks. Our approach combined laser branding of glomeruli of interest with volume-based focused ion beam-scanning electron microscopy to enable precise targeting and analysis of the two glomeruli. We discovered differences in their neuronal innervation, synaptic compos

SUBMITTER: Gruber L 

PROVIDER: S-EPMC12537010 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature