Origin and evolution of signaling pathways responsible for ascorbic acid synthesis and catabolism during plant terrestrialization.

ABSTRACT: This study comprehensively reveals the origin and evolution mechanisms of ascorbic acid (AsA) synthesis and breakdown pathways during plants' transition from water to land. By analyzing genomic data from 21 key plant species and transcriptomic data from the One Thousand Plants transcription project, we found that the L-galactose pathway emerged in green algae, with variations in the HIT domain of the rate-limiting enzyme GGP driving adaptive divergence between lower and higher plants. The galacturonic acid pathway integrated with the L-galactose pathway through the emergence of GalUR in bryophytes. The myo-inositol pathway became complete in bryophytes, and its refinement likely promoted dehydration adaptation via oxidative protection. The AsA recycling pathway (APX/MDHAR/DHAR) orig

SUBMITTER: Su LY 

PROVIDER: S-EPMC12537018 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature