SMUG1 promoted the progression of pancreatic cancer via AKT signaling pathway through binding with FOXQ1.

ABSTRACT:

Background

Pancreatic cancer is a lethal malignancy prone to gemcitabine resistance. The single-strand selective monofunctional uracil DNA glycosylase (SMUG1), which is responsible for initiating base excision repair, has been reported to predict the outcomes of different cancer types. However, the function of SMUG1 in pancreatic cancer is still unclear.

Methods

Gene and protein expression of SMUG1 as well as survival outcomes were assessed by bioinformatic analysis and verified in a cohort from Fudan University Shanghai Cancer Center. Subsequently, the effect of SMUG1 on proliferation, cell cycle, and migration abilities of SMUG1 cells were detected in vitro . DNA damage repair, apoptosis, and gemcitabine resistance were also tested. RNA sequencing was performed to determin

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12537221 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature