Association between endometrial cancer and subsequent risk of fracture: a national cohort study.

ABSTRACT:

Aims

Most endometrial cancer (EC) cases are estrogen-dependent, and some are associated with diabetes mellitus (DM). We aimed to estimate the risk of fracture among patients with EC and those with DM.

Materials and methods

A total of 20814 patients with EC were identified from the Taiwan National Cancer Registry from 2007 to 2018, with the outcome ascertainment using the National Health Insurance Research Database from 2004 to 2019. This observational study investigated the hazard ratios (HRs) for fracture and mortality events using Cox proportional hazards regression, with 95% confidence intervals (CIs). We adjusted baseline comorbidities, cancer therapy, cancer staging and grade, and pathological status of estrogen receptor and progesterone receptor. Considering the compet

SUBMITTER: Tsai WH 

PROVIDER: S-EPMC12537369 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature