Pharmacological treatment options for cognitive dysfunction induced by multiple sclerosis: a network meta-analysis.

ABSTRACT:

Objectives

To compare the effects of various pharmacological treatments on partial test results and adverse effects in patients with cognitive dysfunction (CD) induced by multiple sclerosis (MS) through a network meta-analysis.

Methods

PubMed, Embase, Cochrane Library, and Web of Science databases were systematically retrieved for randomized controlled trials (RCTs) evaluating the influence of different pharmacological treatments on CD in MS patients. The search was updated until October 8, 2024. The Risk of Bias tool was used to assess the quality of eligible studies, and R was employed for data analysis.

Results

Twenrt six studies involving 23,839 MS patients were included for our analysis. Network meta-analysis results indicated that compared to placebo, L-amphetam

SUBMITTER: Fan Z 

PROVIDER: S-EPMC12537379 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature