Efficacy of combined gonadotropin-releasing hormone analogue and growth hormone therapy in girls with central precocious puberty: a systematic review and meta-analysis.

ABSTRACT:

Background

Central precocious puberty (CPP) in girls is characterized by premature activation of the hypothalamic-pituitary-gonadal axis, often leading to early epiphyseal closure and compromised adult height. While gonadotropin-releasing hormone analogues (GnRHa) are the standard therapy to suppress puberty and preserve height potential, the benefit of adding growth hormone (GH) to improve height outcomes remains unclear. This work aims to evaluate the efficacy of combined GnRHa and GH therapy compared to GnRHa monotherapy in improving growth outcomes in girls with CPP.

Methods

A systematic search of PubMed, Embase, Web of Science, and Cochrane Library was conducted up to May 2025. Eligible studies comparing GnRHa + GH combination therapy to GnRHa monotherapy in girls with

SUBMITTER: Jin S 

PROVIDER: S-EPMC12537404 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature