Construction of a prognostic model for colorectal cancer liver metastasis based on single-cell transcriptomics and regulation of the MIF pathway.

ABSTRACT:

Introduction

Colorectal cancer is associated with a generally poor prognosis, primarily due to its often late diagnosis and the high propensity for liver metastasis. Current treatment strategies emphasize personalized approaches, integrating advanced targeted therapies based on specific molecular profiles to enhance outcomes. Continued research into molecular targets and innovative treatments is crucial for improving survival rates and managing disease progression.

Methods

We retrieved single-cell transcriptomic and bulk RNA-seq data from colorectal cancer samples in the GEO and TCGA databases. The analysis focused on changes in pathway and gene expression in epithelial cells during the metastatic progression. A prognostic risk model was developed based on differentially exp

SUBMITTER: Cao J 

PROVIDER: S-EPMC12537406 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature