Efficacy of Oseltamivir Against Seasonal Influenza H1N1 and the Efficacy of a Novel Combination Treatment In Vitro and In Vivo in Mouse Studies.

ABSTRACT:

Background

Influenza surveillance and drug resistance testing have always been central to clinical efforts. Therefore, researching the virus characteristics and antiviral drugs is essential.

Method

The HA and NA activities were assessed in influenza strains, and mutations were identified through gene sequencing. The effects of oseltamivir, molnupiravir, and baloxavir treatments were evaluated in vitro. The effectiveness of molnupiravir monotherapy and its combination with baloxavir was also evaluated in a mouse model. Changes in body weight and lung tissue were examined, including pathological changes, virus replication, and inflammation levels.

Results

Forty-one seasonal influenza H1N1 strains from 2023 were used. The EC₅₀ of oseltamivir was significantly

SUBMITTER: Liu D 

PROVIDER: S-EPMC12537536 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature