Injectable hemostatic foam hydrogel for traumatic intra-abdominal hemorrhage.

ABSTRACT: Traumatic abdominal hemorrhage is critically life-threatening, as uncontrolled bleeding in this region can rapidly lead to death. However, there is a lack of effective methods or materials for emergency hemorrhage control, especially for pre-hospital emergency medical services. Here, we report an injectable hemostatic foam (IHF), a norepinephrine-loaded sodium alginate/carboxymethyl chitosan-based foam, which was inspired by physiological hemostasis processes (vasoconstriction, platelet thrombosis, and blood coagulation). IHF possesses good injectability, can rapidly reach the injury site to create a tamponade effect and provide wound site coverage when injected into abdominal cavity during emergency care. Then, the loaded norepinephrine induces vasoconstriction, and the foam interacts wit

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12537577 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature