Diffusion-weighted imaging-derived parameters as quantitative imaging biomarkers in magnetic resonance-guided radiotherapy: a systematic review.

ABSTRACT:

Background and purpose

Magnetic Resonance Linear Accelerators (MR-LINACs) have transformed radiotherapy by integrating high-resolution magnetic resonance imaging (MRI) with precise radiation delivery. Diffusion-Weighted Imaging (DWI)-derived parameters are promising non-invasive quantitative imaging biomarkers (QIBs) for MR-guided radiotherapy (MRgRT), primarily through apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) models; however, their clinical utility and validation on MR-LINAC systems remain underexplored. This systematic review evaluates DWI's technical development, validation, and clinical role in MRgRT using MR-LINACs.

Material and methods

Following PRISMA guidelines, PubMed/MEDLINE, Web of Science, and Scopus (2014-2024) were searched f

SUBMITTER: Yuan J 

PROVIDER: S-EPMC12537581 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature