Perioperative leukocyte-plateletcrit shift as a prognostic signature in glioblastoma.

ABSTRACT:

Purpose

Circulating inflammatory indices derived from routine blood counts may offer pragmatic prognostic information in glioblastoma (GB), yet the prognostic role of plateletcrit (PCT) and of peri-treatment dynamics in leukocyte-platelet coupling remains underexplored.

Methods

We retrospectively studied 95 adults with histologically confirmed GB (48 men, 47 women; median age 64.5 years) treated adjuvantly with radiotherapy and chemotherapy with complete blood counts obtained at four windows: pre-operative, post-operative, pre-adjuvant, and post-adjuvant. From leukocytes, platelets (PLT), plateletcrit (PCT), and mean platelet volume (MPV) we derived all within-timepoint ratios and inter-timepoint differences (Δ). Overall survival (OS) in days was modeled using Cox proportion

SUBMITTER: Krupa P 

PROVIDER: S-EPMC12537585 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature