Preliminary investigation of the association between desmoglein-2 expression and patient prognosis following radical surgery for colon cancer.

ABSTRACT:

Background

Desmoglein-2 (DSG2), a calcium-dependent transmembrane glycoprotein, serves as a critical mediator of intercellular adhesion by functioning as an integral component of desmosomal junctions. Aberrant expression of DSG2 has been implicated in the pathogenesis of a diverse array of malignancies. However, the expression patterns and functional significance of DSG2 in the context of colon cancer (CC) remain inadequately characterized. Consequently, this study was designed to comprehensively elucidate DSG2 expression and evaluate its potential prognostic utility in CC.

Methods

Tumor specimens from 104 CC patients and 77 samples of adjacent paraneoplastic tissue were procured, accompanied by the corresponding clinicopathological data from the contributing patients. Immun

SUBMITTER: Li Y 

PROVIDER: S-EPMC12537610 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature