Advancing glioblastoma therapy with surface-modified nanoparticles.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is a very aggressive and deadly brain tumor, presenting considerable therapeutic hurdles due to its infiltrative development, heterogeneity, and protective mechanisms of the blood-brain barrier (BBB). Traditional treatment methods frequently do not yield satisfactory results, requiring the implementation of novel solutions. Surface-modified nanoparticles (NPs) have emerged as a viable approach in GBM therapy, providing potential benefits in targeted drug delivery, improved therapeutic efficacy, and reduced systemic toxicity.

Aim

This narrative review examines progress in the creation and utilization of surface-modified NPs, emphasizing their function in traversing the blood-brain barrier and selectively targeting glioblastoma cells.

SUBMITTER: De Rosa G 

PROVIDER: S-EPMC12537612 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature