Molecular detection of HPV, EBV, and polyomaviruses in thyroid tumors and their clinicopathological relevance.

ABSTRACT:

Objective

Oncogenic viruses have been implicated in thyroid carcinogenesis, yet their prevalence and clinicopathological associations remain incompletely understood. Thus, it is crucial to investigate the prevalence of human papillomavirus (HPV), Epstein-Barr virus (EBV), and polyomaviruses (JCV and BKV) in thyroid tumors and assess their association with clinic-pathological characteristics.

Methods

This study included 70 fresh biopsy samples collected from 45 TC patients and 25 patients with benign thyroid tumors, along with 10 normal thyroid tissues. Viral DNA was extracted and screened for HPV, EBV, and polyomaviruses using SYBR Green-based real-time PCR.

Results

HPV, EBV, and polyomaviruses, particularly JCV, were detected at significantly lower frequencies in the

SUBMITTER: Ramadan N 

PROVIDER: S-EPMC12537628 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature