Case Report: Lessons learned from large animal implantation of an all-natural tissue engineered vascular graft.

ABSTRACT: Cardiovascular disease continues to be the number one cause of morbidity and mortality across the world. Coronary artery bypass graft (CABG) procedures are the most commonly performed major surgery in the U.S. Grafts are difficult to source as patients do not have many sites from which to harvest donor tissues as autografts. Plastic grafts have issues of infection and are only used as a last resort. Tissue engineered vascular grafts have potential to solve the need for all-natural vascular grafts in the clinic. In this study, we evaluate the feasibility of a completely biological engineered vascular graft for implantation in a large animal model of a rabbit. An all-biological tissue engineered graft was grown in our laboratory, composed of a tunica adventitia derived from human dermal fibr

SUBMITTER: Dumitru AI 

PROVIDER: S-EPMC12537691 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature