Metabolomic profiling and identification of potential biomarkers of highly pathogenic avian influenza (H5N1) in chicken.

ABSTRACT:

Introduction

Highly Pathogenic Avian Influenza (HPAI) H5N1 is a significant zoonotic pathogen with the potential to cause pandemics. Its high prevalence and mortality rates in poultry, along with a recent expansion in host range, underscore the urgent need to understand the molecular mechanisms underlying its pathogenesis and host-pathogen interactions. Metabolomics, the comprehensive study of small-molecule metabolites within biological systems, offers a promising approach to unravel these mechanisms and aid in the development of effective control strategies against HPAI H5N1.

Methods

To investigate the metabolomic alterations associated with HPAI H5N1 infection, serum and lung samples were collected from specific pathogen-free (SPF) chickens that were either infected with

SUBMITTER: Kadamthodi AM 

PROVIDER: S-EPMC12537707 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature