Impact of atropine on changes in choroidal thickness in children with myopia: a meta-analysis of randomized controlled trials.

ABSTRACT:

Introduction

Atropine is used to treat myopia, and choroidal thickness (ChT) has been suggested as a biomarker for treatment response. However, randomized controlled trials (RCTs) have reported inconsistent results regarding their efficacy. This study aimed to assess the effect of atropine on ChT in children with myopia.

Methods

A systematic review and meta-analysis of RCTs was conducted using PubMed, Cochrane, Embase, and Web of Science databases, including trials registered online, from inception to March 2025. Eligible studies were those that involved patients aged <18 years with myopia treated using atropine sulfate eye drops and reported ChT outcomes. Meta-regression and the Cochrane I ² test were used to assess heterogeneity, respectively. Publication

SUBMITTER: Liu LP 

PROVIDER: S-EPMC12537749 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature