The impact of polygenic risk for alzheimer's disease on neurotransmitter-related grey matter atrophy in the alzheimer continuum.

ABSTRACT: Alzheimer's disease (AD) pathology has been recently shown to accumulate in multiple brainstem nuclei in pre-cortical disease stages. However, the impact of neurotransmission alterations on brain atrophy and their genetic correlates in AD remain unexplored. This study investigated (1) associations between grey matter (GM) loss and uptake values of PET/SPECT ligands tracing concentration of multiple neurotransmitter receptors/transporters and pathways; (2) the impact of AD polygenic risk scores (AD-PRSs) on such associations along the AD continuum. T1-weighted MRI scans, genetic and clinical data were selected for 800 ADNI participants: 203 cognitively unimpaired older adults (CU), 442 with mild cognitive impairment (MCI) and 155 with AD. JuSpace was used to calculate correlations between G

SUBMITTER: Manca R 

PROVIDER: S-EPMC12537760 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature