Dynamics of NK cell subsets following autologous hematopoietic stem cell transplantation in adult oncologic patients.

ABSTRACT: Early immune reconstitution following autologous hematopoietic stem cell transplantation (autoHSCT) is associated with improved outcome in various cancers. Natural killer (NK) cells are the first lymphocyte subset to recover post-autoHSCT and play a crucial role in antitumor immunity. In this study, we have performed an in-depth characterization of NK cells in adult patients with different hematological malignancies. Our results revealed that, immediately after autoHSCT, NK cells transiently acquired a decidual-like phenotype, displayed a more immature and activated state, and exhibited an upregulation of inhibitory receptors and a downregulation of activating receptors. This decidual-like and activated phenotype was characterized by increased expression of CD56, CD9, CD49a, CD151, CD38 an

SUBMITTER: Astarloa-Pando G 

PROVIDER: S-EPMC12537779 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature