Exploring the molecular intersection for hypertension, hyperlipidemia and their comorbid conditions through multi-omics approaches.

ABSTRACT:

Background

Hypertension and hyperlipidemia are interconnected conditions that heighten cardiovascular risk, yet their intricate multi-scale molecular signatures remain inadequately mapped. This study aimed to conduct an integrated multi-omics investigation to unravel the key pathways and biomarkers underlying hypertension, hyperlipidemia, and both conditions.

Methods

Metabolomic analysis was performed on serum samples and metagenomic analysis on fecal samples collected from individuals with hypertension (n = 16), hyperlipidemia (n = 19), or both conditions concurrently (n = 20). In addition, 20 healthy individuals were recruited as controls.

Results

Metabolomics uncovered altered levels of sphingolipids, phosphatidylcholines, glycylprolines, and n

SUBMITTER: Li W 

PROVIDER: S-EPMC12537794 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature