Entorhinal grid-like codes for visual space during memory formation.

ABSTRACT: Eye movements, such as saccades, allow us to gather information about the environment and, in this way, can shape memory. In non-human primates, saccades are associated with the activity of grid cells in the entorhinal cortex. Grid cells are essential for spatial navigation, but whether saccade-based grid-like signals play a role in human memory formation is currently unclear. Here, human participants undergo functional magnetic resonance imaging and continuous eye gaze monitoring while studying scene images. Recognition memory is probed immediately thereafter. Results reveal saccade-based grid-like codes in the left entorhinal cortex that are specific to later remembered trials during study, a finding that we replicate with an independent data set. The grid-related effects are time-locked

SUBMITTER: Graichen LP 

PROVIDER: S-EPMC12537863 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature