Goal-directed behavior and hippocampal activity predict real-life impact of drinking intentions in alcohol use disorder.

ABSTRACT: A shift away from goal-directed, model-based behavior is commonly viewed to characterize alcohol use disorder (AUD). Previous research, however, has failed to demonstrate differences between individuals with and without AUD regarding goal-directed control, operationalized as model-based behavior. Instead, findings suggest associations between model-based behavior and alcohol consumption patterns, but mechanistic insights into the link between model-based behavioral and neural signatures and longitudinal, real-life control over alcohol intake remain elusive. Here, we investigated whether experimentally assessed model-based behavior can prospectively predict intentional reduction of alcohol consumption in daily life. Therefore, we related behavioral and neural markers of model-based behavior

SUBMITTER: Ebrahimi C 

PROVIDER: S-EPMC12537898 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature