Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis.

ABSTRACT: Cardiac amyloidosis (CA) occurs when misfolded proteins deposit as fibrils in the extracellular space of the heart. The fibrillogenic properties of apolipoprotein A-IV (ApoAIV) have been histologically observed and associated with CA pathogenesis. We report the structure of an ApoAIV amyloid from a patient's heart, which coexist amongst transthyretin (TTR) amyloids. These cases of undetected mixed CA highlight the importance of developing broad-spectrum anti-amyloid treatments to improve outcomes in patients.

SUBMITTER: Aibara S 

PROVIDER: S-EPMC12537937 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature