Optineurin is an adaptor protein for ubiquitinated substrates in Golgi membrane-associated degradation.

ABSTRACT: Golgi membrane-associated degradation (GOMED) is a process that leading to the degradation of proteins that have passed through the trans-Golgi membranes upon Golgi stress. GOMED is morphologically similar to autophagy, but the substrates degraded are different, and they thus have different biological roles. Although the substrate recognition mechanism of autophagy has been clarified in detail, that of GOMED is completely unknown. Here we report that GOMED degrades its substrate proteins selectively via optineurin (OPTN), as we found that the degradation of GOMED substrates is s`uppressed by the loss of OPTN. OPTN binds to K33 polyubiquitin-tagged proteins that have passed through the Golgi, which are then incorporated into GOMED structures for eventual degradation. In vivo, GOMED is known

SUBMITTER: Nibe-Shirakihara Y 

PROVIDER: S-EPMC12537940 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature